&lt;p&gt;Currently, the Air Quality Monitor (AQM) on-board ISS provides specific information for a number of target compounds in the air. However, there is a significant subset of common target compounds between air and water.&amp;nbsp; Naturally, the following question arises, &amp;ldquo;Can the AQM be used for both air and water quality monitoring?&amp;rdquo;&amp;nbsp; Previous directorate-level IR&amp;amp;D funding led to the development of a water sample introduction method for mass spectrometry using electro-thermal vaporization (ETV).&amp;nbsp; This vaporization source allows analytes in water samples to enter the gas phase, where they can be analyzed using a variety of techniques.&amp;nbsp; This project will focus on the integration of the ETV with a ground-based AQM.&amp;nbsp; The capabilities of this integrated platform will be evaluated using a subset of toxicologically important compounds.&lt;/p&gt;&lt;p&gt;The ETV unit was constructed using two glass tubes and a nichrome ribbon powered by a programmable DC power supply (G W Instec, PSM-3004).&amp;nbsp; The nichrome ribbon was threaded through two 3-mm wide, 1-cm-long slot cuts on the inner tube placed 1.5 cm past the inlet.&amp;nbsp; The ribbon was held securely by compressing it between the inner tube and two halves of an outer glass tube.&amp;nbsp; These halves were held together using a flexible metal clamp.&amp;nbsp; Inside the inner tube the ribbon was slightly curved, and an indent (1 mm diameter) was made on its surface for depositing a measured liquid sample drop.&amp;nbsp; The ribbon was positioned in the upper half of the inner tube in such a way that the edge of the ribbon faced the front (inlet) side of the ETV unit.&amp;nbsp; Holes (1 mm diameter) were made on the outer and inner glass tubes for sample introduction and were aligned with the ribbon indent.&lt;/p&gt;&lt;p&gt;The viability of the ETV approach for the analysis of water analytes was demonstrated using a ground-based, laboratory scale analyzer (reference:&amp;nbsp; Dwivedi, P. et al.&amp;nbsp; &amp;ldquo;Electro-Thermal Vaporization Direct Analysis in Real Time-Mass Spectrometry for Water Contaminant Analysis During Space Missions,&amp;rdquo; Analytical Chemistry, 85, 9898-9906 (2013)).&amp;nbsp; The work in this proposal will extend that effort and interface the ETV to a ground version of the current in-flight AQM.&amp;nbsp; Liquid sample will be introduce via a pipet through the sample injection port and placed onto the nichrome ribbon heated to a set temperature by an external, programmable power supply.&amp;nbsp; Upon vaporization of the water sample, the target analytes will be swept into the AQM Sample-In port using nitrogen carrier gas.&amp;nbsp; A vapor-phase analysis can then be performed by the AQM to identify and quantify the target analytes in the water samples.&amp;nbsp; Parameters to be optimized include water sample size, carrier gas sweep rate, and ribbon temperature.&amp;nbsp; The operating parameters of the vapor-phase analysis performed by the AQM will also need to be modified for this type of sampling methodology.&amp;nbsp; A simple two-position valve attached to the ETV and a diverter tube will allow for manual selection of either a water sample through the ETV or an air sample through the diverter tube.&amp;nbsp; The primary objective of this effort is to evaluate the viability of the ETV with ground-based, flight hardware.&amp;nbsp; A proof-of-concept unit capable of water and air analysis utilizing the ETV will be developed.&amp;nbsp; The target water analytes to be used in this work will come from a list provided by the water SMEs in the Toxicology and Environmental Chemistry Laboratories at JSC.&amp;nbsp; These analytes are commonly observed in the ground analysis of water samples from ISS.&amp;nbsp; A preliminary engineering evaluation of this set-up could potentially be performed with the goal of formulating a viable plan of integrating the ETV to the control software and power supply of the AQM.&amp;nbsp; This plan could serve as a starting point for further development.&amp;nbsp; This work will advance this project from a TRL of 3 to a TRL of 5. &amp;nbsp;&lt;br /&gt;&amp;nbsp;&lt;/p&gt;&lt;p&gt;&amp;nbsp;&lt;/p&gt;